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S6448

Sigma-Aldrich

SYK, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

Nivel de calidad

200

Línea del producto

PRECISIO® Kinase

ensayo

≥70% (SDS-PAGE)

formulario

buffered aqueous glycerol solution

specific activity

79-107 nmol/min·mg

mol peso

~100 kDa

Nº de acceso UniProt

enfermedades relevantes

cancer

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... SYK(6850)

Acciones bioquímicas o fisiológicas

SYK is a non-receptor protein tyrosine kinase that is widely expressed in hematopoietic cells. It is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. In B cells, SYK plays a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement.SYK has been shown to act as a potential tumor suppressor in breast cancer. Absence of SYK protein in primary breast tumors is correlated with poor outcomes. SYK deficient cells have increased motility that is restored to normalcy by replacement with wild-type SYK.

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Información legal

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificate of Analysis

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Certificate of Origin

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