S7076

SB 202190 monohydrochloride hydrate

≥98% (HPLC)

• Synonym(s): 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate, 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
• Empirical Formula (Hill Notation): C₂₀H₁₄FN₃O · HCl · xH₂O
• CAS Number: 350228-36-3
• Molecular Weight: 367.80 (anhydrous basis)
• Número MDL: MFCD17215958
• ID de la sustancia en PubChem: 329824576
• NACRES: NA.77

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: solid
• color: white to beige
• solubilidad: DMSO: ≥12 mg/mL
• emisor: GlaxoSmithKline
• temp. de almacenamiento: 2-8°C
• SMILES string: O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2
• InChI key: CZZOICWZVYZUNP-UHFFFAOYSA-N

Description

Aplicación

SB 202190 may be used to inhibit p38-mediated cell signaling.

SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium and organoid culture medium It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.

SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.

SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.

Características y beneficios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315 - H319 - H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable