Merck

SAB4200415

Sigma-Aldrich

Anti-NEZHA antibody, Mouse monoclonal

clone NEZHA-1, purified from hybridoma cell culture

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Sinónimos:
Anti-CAMSAP3, Anti-Calmodulin regulated spectrin-associated protein family member 3, Anti-KIAA, Monoclonal Anti-NEZHA antibody produced in mouse
NACRES:
NA.41

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

purified from hybridoma cell culture

antibody product type

primary antibodies

clon

NEZHA-1, monoclonal

formulario

buffered aqueous solution

mol peso

antigen ~150 kDa

species reactivity

canine, human

concentración

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: 2.5-5.0 μg/mL using whole extracts of human SW480 cells

isotipo

IgG1

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

target post-translational modification

unmodified

Gene Information

human ... CAMSAP3(57662)
mouse ... Camsap3(69697)

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Este artículo
SAB4200365SAB4200503SAB4200005
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

clone

NEZHA-1, monoclonal

clone

PIWIL1-2, monoclonal

clone

1L4, monoclonal

clone

UVRAG-11, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

antigen ~150 kDa

mol wt

antigen ~95 kDa

mol wt

antigen ~60 kDa

mol wt

antigen ~90 kDa

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Descripción general

Monoclonal Anti-NEZHA (mouse IgG1 isotype) is derived from the hybridoma NEZHA-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of human NEZHA, conjugated to KLH. Nezha (a deity in Chinese mythology) also known as KIAA1543 and calmodulin-regulated spectrin associated protein, is a 1276 amino acid protein that contains one calponin homology (CH) and two coiled coil (CC1 and 2) domains, as well as one DUF1781 (DUF) domain of unknown function. NEZHA is mapped to human chromosome 19p13.
NEZHA/ calmodulin regulated spectrin associated protein family member 3 (CAMSAP3) contains a conserved domain called cholecystokinin (CKK) domain at carboxy-terminal, as well as several coiled-coil regions and an calponin homology domain at amino-terminal.

Inmunógeno

synthetic peptide corresponding to a sequence at the C-terminal region of human NEZHA, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and dog NEZHA.

Aplicación

Monoclonal Anti-NEZHA antibody produced in mouse has been used in immunofluorescence staining.
Monoclonal Anti-NEZHA antibody produced in mouse has been used in:
  • immunofluorescence
  • immunoprecipitation
  • immunofluorescence
  • mass-spectrometry-based analysis of a streptavidin pull-down assay
  • immunostaining

Acciones bioquímicas o fisiológicas

CAMSAP3 (calmodulin-regulated spectrin-associated protein 3)/ NEZHA modulates the minus-end dynamics of microtubules. It helps to maintain neuronal polarity. Absence of this gene results in the formation of supernumerary axon.
NEZHA/ calmodulin regulated spectrin associated protein family member 3 (CAMSAP3) facilitates translocation of Golgi vesicles in epithelial cells. In addition, it also helps in positioning the apical-to-basal polarity of microtubules in epithelial cells.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling
Kourtidis A, et al.
The Journal of cell biology, 216(10), 3073-3085 (2017)
CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells.
Toya M
Proceedings of the National Academy of Sciences of the USA, 113, 332-337 (2016)
CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells.
Wang J
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 44, 39-49 (2017)
Laure Coquand et al.
The Journal of cell biology, 220(8) (2021-05-22)
Neurons of the neocortex are generated by stem cells called radial glial cells. These polarized cells extend a short apical process toward the ventricular surface and a long basal fiber that acts as a scaffold for neuronal migration. How the
Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk
Permuth JB, et al.
Human Molecular Genetics, 25(16), 3600-3612 (2016)

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