Merck

SAB4200468

Sigma-Aldrich

Anti-JAM-A antibody, Mouse monoclonal

clone J10.4, purified from hybridoma cell culture

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Sinónimos:
Monoclonal Anti-CD321, Monoclonal Anti-F11 receptor, Monoclonal Anti-F11R, Monoclonal Anti-JAM, Monoclonal Anti-JAM1, Monoclonal Anti-JAMA, Monoclonal Anti-JCAM, Monoclonal Anti-KAT, Monoclonal Anti-PAM-1
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

J10.4, monoclonal

form

buffered aqueous solution

mol wt

antigen 37 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 1.0-2.0 μg/mL using HepG2 or A431 or A549 total cell extracts

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... F11R(50848)

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Este artículo
SAB4200473SAB4200365SAB4200544
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... F11R(50848)

Gene Information

human ... EPCAM(4072)
mouse ... Epcam(17075)

Gene Information

human ... PIWIL1(9271)
mouse ... Piwil1(57749)

Gene Information

human ... SYP(6855)

clone

J10.4, monoclonal

clone

4A7, monoclonal

clone

PIWIL1-2, monoclonal

clone

SVP-38, monoclonal

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

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General description

Anti-JAM-A antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the hybridoma J10.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human JAM. Junctional adhesion molecule A (JAM-A) is expressed at tight junctions of endothelial and epithelial cells as well as on a variety of hematopoietic cells. It belongs to the transmembrane IgG glycoprotein family and is also expressed in monocytes, lymphocytes, neutrophils, dendritic cells, platelets, and spermatozoa. The JAM-A or F11R gene is mapped to human chromosome 1q23.3.

Specificity

Anti-JAM-A antibody, Mouse monoclonal recognizes human JAM-A.

Immunogen

derived from the hybridoma J10.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human JAM fusion protein.

Application

Anti-JAM-A antibody, Mouse monoclonal has been used in:
  • western blotting
  • staining for confocal microscopy
  • immunoprecipitation
  • immunocytochemistry
  • flow cytometry

Biochem/physiol Actions

Junctional adhesion molecule A(JAM-A) function has been linked with regulation of cell migration/invasion, platelet adhesion, cell polarity, cell proliferation, and epithelial or endothelial barrier function. However, the mechanisms by which JAM-A mediates these processes have not been well elucidated. JAM-A functional significance is connected with inflammation, angiogenesis, hypertension, ischemia/reperfusion, and atherosclerosis. JAM-A has also been linked to breast, endometrial, renal cell carcinomas and gastric cancer.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Hisato Koshiba et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19(2), 208-213 (2009-04-28)
Junctional adhesion molecule A (JAM-A) is involved in cell-cell contact and tight junction formation. Loss of cell adhesion molecules may be associated with high histologic grade and invasiveness of endometrial carcinoma. We attempted to determine JAM-A expression in human endometrial
Stefania Vetrano et al.
Annals of the New York Academy of Sciences, 1165, 308-313 (2009-06-23)
Tight junctions (TJ) are junctional proteins whose function is to maintain an intact intestinal epithelial barrier and regulate the paracellular movement of water and solutes. Altered TJ structure and epithelial permeability are observed in inflammatory bowel disease and seem to
Tim Steinbacher et al.
Cellular and molecular life sciences : CMLS, 75(8), 1393-1409 (2017-12-15)
Cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IgSF) regulate important processes such as cell proliferation, differentiation and morphogenesis. This activity is primarily due to their ability to initiate intracellular signaling cascades at cell-cell contact sites. Junctional adhesion molecule-A (JAM-A)
Paul Gutwein et al.
Biochemical and biophysical research communications, 380(2), 387-391 (2009-03-03)
Junctional adhesion molecule-A (JAM-A) is one component of tight junctions which are involved in important processes like paracellular permeability, cell polarity, adhesion, migration, and angiogenesis. Here we describe JAM-A expression in distal convoluted tubule, connecting tubule, and in cells of
Association of rs61803665 Polymorphism in the F11R Gene with Increased Risk of Gastric Cancer
Khalili Z, et al.
Asian Pacific Journal of Cancer Biology, 4(1), 15-18 (2019)

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