Merck

SAB4200511

Sigma-Aldrich

Anti-FUS (internal region) antibody produced in rabbit

affinity isolated antibody

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Sinónimos:
Anti-HNRNPP2, Anti-TLS, Anti-fus-like protein, Anti-fused in sarcoma, ALS6, FUS1, POMP75, 75 kDa DNA-pairing protein, Anti-fusion gene in myxoid liposarcoma, Anti-heterogeneous nuclear ribonucleoprotein P2, Anti-translocated in liposarcoma protein
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

antibody product type

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~70 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: 2.5-5.0 μg/mL using human HepG2 or MCF7 cells.
western blot: 0.5-1.0 μg/mL using whole extracts of human HEK-293T or G361 cells.

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

target post-translational modification

unmodified

Gene Information

human ... FUS(2521)

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Este artículo
SAB4200454HPA008784SAB5700228
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

mol wt

antigen ~70 kDa

mol wt

antigen ~68 kDa

mol wt

-

mol wt

53

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Descripción general

Fused in sarcoma (FUS) is a component of heterogeneous nuclear ribonucleoprotein (hnRNP) complex. FUS gene is mapped to human chromosome 16p11.2. FUS is located predominantly in the nucleus.

Especificidad

Anti-FUS (internal region) recognizes human FUS.

Inmunógeno

peptide corresponding to an internal region of human FUS, conjugated to KLH. The corresponding sequence is identical in monkey and differs by 4 amino acids in rat and mouse.

Aplicación

Anti-FUS (internal region) antibody produced in rabbit may be used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Acciones bioquímicas o fisiológicas

Fused in sarcoma (FUS), also called translocation in liposarcoma or Tumor lysis syndrome (TLS), plays a key role in RNA splicing, DNA repair and transcriptional regulation. It is a RNA/DNA binding protein implicated in various diseases. Mutations in the FUS gene is implicated in familial amyotrophic lateral sclerosis (FALS). Chromosomal translocation of FUS/TLS is found in human cancers and results in the production of oncogenic FUS fusion proteins. FUS has been implicated in a broadening spectrum of neurodegenerative disorders and is a component of inclusion bodies in patients with Huntington′s disease (HD) and spinocerebellar ataxias (SCA1) and SCA3. The majority of the FUS mutations have been identified in the C-terminal nuclear localization signal (NLS). TAR DNA-binding protein 43 (TDP-43) and FUS have been identified in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FLTD) and familial amyotrophic lateral sclerosis (FALS). Pathological FUS inclusions are mostly found in the cytosol of neurons and glial cells.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
Vance C, et al.
Science (New York, N.Y.), 323(5918), 1208-1211 (2009)
Hao Deng et al.
Nature reviews. Neurology, 10(6), 337-348 (2014-05-21)
The neurodegenerative diseases are a diverse group of disorders characterized by progressive loss of specific groups of neurons. These diseases affect different populations, and have a variable age of onset, clinical symptoms, and pathological findings. Variants in the FUS gene
TDP-43 and FUS: a nuclear affair
Dormann D and Haass C
Trends in Neurosciences, 34(7), 339-348 (2011)
Fused in sarcoma: Properties, self-assembly and correlation with neurodegenerative diseases
Chen C, et al.
Molecules (Basel), 24(8), 1622-1622 (2019)
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
Lagier-Tourenne C, et al.
Human Molecular Genetics, 19(R1), R46-R64 (2010)

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