Merck

SAB4200820

Sigma-Aldrich

Anti-Fetuin A antibody, Mouse monoclonal

clone FetA-M, purified from hybridoma cell culture

Iniciar sesiónto View Organizational & Contract Pricing

Select a Size

Sinónimos:
Alpha-2-HS-glycoprotein (AHSG), Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein
NACRES:
NA.41

origen biológico

mouse

forma del anticuerpo

purified from hybridoma cell culture

antibody product type

primary antibodies

clon

FetA-M, monoclonal

species reactivity

human

envase

antibody small pack of 25 μL

concentración

~1 mg/mL

technique(s)

immunoblotting: 2-4 μg/mL using Human serum

isotipo

IgM

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−20°C

target post-translational modification

unmodified

Gene Information

human ... AHSG(197)

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo
SAB4200746SAB4200198SRP6217
Sigma-Aldrich

Sigma-Aldrich

SRP6217

Fetuin A/ASHG human

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

-

clone

FetA-M, monoclonal

clone

C3, monoclonal

clone

1C2, monoclonal

clone

-

species reactivity

human

species reactivity

human, canine, porcine

species reactivity

human

species reactivity

-

packaging

antibody small pack of 25 μL

packaging

-

packaging

-

packaging

pkg of 10 and 50 μg

concentration

~1 mg/mL

concentration

~1.0 mg/mL

concentration

~1.0 mg/mL

concentration

-

Descripción general

Fetuin A, also known as Alpha-2-HS-glycoprotein (AHSG), Alpha-2-Z-globulin or Ba-alpha-2-glycoprotein, is a member of the cystatin superfamily of cysteine protease inhibitors. Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver Hepatocytes. It is cleaved into two chains bound by disulfide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Monoclonal Anti-Fetuin A (mouse IgM isotype) is derived from the Fet A-M hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a BALB/C mouse immunized with a synthetic peptide corresponding to the internal region of human AHSG (Fetuin A), conjugated to KLH as immunogen. Fetuin A is a 64 kDa protein, predominantly localized to the blood.

Especificidad

Monoclonal Anti-Fetuin A specifically recognizes Fetuin A from human plasma.

Inmunógeno

Synthetic peptide corresponding to human Fution A internal region, conjugated to KLH

Aplicación

The antibody is recommended for use in various immunological techniques including Immunoblotting, Immunohistochemistry and ELISA.

Acciones bioquímicas o fisiológicas

Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver hepatocytes. It is cleaved into two chains bound by disulphide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Reduction in the serum fetuin might indicate coronary artery disease. Fetuin is also implicated in insulin resistance and metabolic syndrome. Increased levels of fetuin A is observed in non-alcoholic fatty liver disease.
Fetuin A is consider to be a negative acute-phase reactant and its serum concentration decreases in response to inflammation, compared with normal levels. In addition, it acts as a mineral chaperone to facilitate the transport and removal of potentially proinflammatory and procalcific cargo (waste).Fetuin A plays a major role in numerous diseases and pathophysiological conditions involved with calcium metabolisms.

Forma física

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Almacenamiento y estabilidad

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Las referencias de los producto se combinan con los tamaños de envase y las cantidades cuando se muestran en la página web, por ejemplo: T1503-25G. Asegúrese de introducir el número de producto ÚNICAMENTE en el campo del Número de producto (ejemplo: T1503).

Ejemplo

T1503
Referencia del producto
-
25G
Tamaño del envase/cantidad

Otros ejemplos

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

introducir como 1.000309185)

¿Tiene algún problema? No dude en ponerse en contacto con nosotros Servicio técnico para asistencia

Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch».

Productos Aldrich

  • Si encuentra un número de lote como TO09019TO, introduzca el número de lote 09019TO sin las dos primeras letras.

  • Si encuentra un número de lote con un código de entrada como 05427ES-021, introduzca el número 05427ES sin el código de entrada -021.

  • Si encuentra un número de lote con un código de entrada como STBB0728K9, introduzca el código de lote STBB0728 sin el código de entrada K9.

¿No ha encontrado lo que estaba buscando?

En algunos casos, puede que un COA no esté disponible en la página web. Si su búsqueda no encontró el COA puede solicitarlo.

Solicitar COA

The relationship of circulating fetuin-a with liver histology and biomarkers of systemic inflammation in nondiabetic subjects with nonalcoholic fatty liver disease
Celebi G, et al.
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 21(3), 139-139 (2015)
Emerging human Fetuin A assays for biomedical diagnostics
Vashist SK, et al.
Trends in biotechnology, 35(5), 407-421 (2017)
Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions
Kutikhin AG, et al.
Scientific Reports, 6, 27255-27255 (2016)
Chelsea Miller et al.
Journal of biomedical materials research. Part A, 111(8), 1096-1109 (2023-01-03)
Surface modifications can be applied to biomaterials to alter the various surface properties that influence protein-material interactions and the cellular response. The plasma protein fetuin-A has been found to adsorb to many biomaterials but details of its interactions with polydimethylsiloxane

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico