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SAB4300123

Sigma-Aldrich

Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit

affinity isolated antibody

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Sinónimos:
Anti-JAK1A antibody produced in rabbit, Anti-JAK1B antibody produced in rabbit, Anti-JTK3 antibody produced in rabbit, Anti-Janus kinase 1 (a protein tyrosine kinase) antibody produced in rabbit
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

antibody product type

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

~130 kDa

species reactivity

rat, mouse, human

concentración

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotipo

IgG

secuencia del inmunógeno

(K-E-YP-Y-T)

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

target post-translational modification

phosphorylation (pTyr1022)

Gene Information

human ... JAK1(3716)

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Este artículo
SAB4501597SAB4300124SAB4300135
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

~130 kDa

mol wt

antigen 131 kDa

mol wt

~125 kDa

mol wt

61-67 kDa, 68-74 kDa

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Descripción general

Janus kinase 1 (JAK1) is encoded by the gene mapped to human chromosome 1p31.3. The encoded protein is one of the four members of the mammalian JAK families. Members of JAK family contain an N-terminal FERM (four.1, ezrin, radixin, moesin) domain, through which they interact with cytokine receptors. The N-terminal end also contains an SH2-like domain. In addition, it also contains a kinase domain and a pseudo-kinase domain, which is catalytically inactive. JAK1 is ubiquitously expressed. When expressed without their receptors, JAKs reside in the cytosol. However, under normal cell conditions, they localize to plasma membrane and endosomes.

Inmunógeno

Peptide sequence around phosphorylation site of tyrosine 1022 (K-E-Y(p)-Y-T), according to the protein JAK1.

Aplicación

Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit has been used in Western blot analysis.

Acciones bioquímicas o fisiológicas

Janus kinases (JAKs) are activated when cytokines bind with their receptors, upon which they phosphorylate the receptors and produce docking sites for signaling molecules. One of the main signaling molecules includes signal transducer and activator of transcription (Stat) family. JAK1 is needed by multiple cytokines, including the family using the shared receptor subunit called common γ chain (γc), such as interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15 and IL-21. JAK1 KO (knockout) mice have early postnatal lethal or perinatal lethal phenotype due to neurological defects. In vitro studies show that JAK1S703I mutation functions as an activator of JAK-STAT pathways even in the absence of cytokines, and drives cellular proliferation. JAK1S703I mutant patient-derived xenograft (PDX) HCC (hepatocellular carcinoma) cells also show sensitivity to JAK1/2 inhibitor, ruxolitinib.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descripción de destino

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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MiR-1246 Promotes LPS-Induced Inflammatory Injury in Chondrogenic Cells ATDC5 by Targeting HNF4γ.
W Da-Peng, et al.
Cellular Physiology and Biochemistry, 43(5), 2010-2021 (2017)
Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
Yang S, et al.
Oncotarget, 7(5), 5461?5469-5461?5469 (2016)
Da-Peng Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(5), 2010-2021 (2017-10-23)
Osteoarthritis (OA) is a common inflammatory joint disease. miRNAs are associated with OA and functionally implicated in the pathogenesis of the disease. In the present study, we investigated the role of miR-1246 in the lipopolysaccharide (LPS)-induced inflammatory injury of ATDC5
The Janus kinases (Jaks).
Yamaoka K et al
Genome Biology, 5(12), 253-253 (2004)

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