SAB5700255

Sigma-Aldrich

Anti-NOTCH1 antibody produced in rabbit

Sinónimos:
AOVD1, NOTCH1, hN1, AOS5, Activated NOTCH1, TAN1, notch 1
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

272

species reactivity

mouse, rat, human

concentration

1 mg/ml

application(s)

immunofluorescence: 1:50-1:200
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NOTCH1(4851)

General description

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

Immunogen

A synthetic peptide of human NOTCH1

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

WGK Germany

WGK 1

Flash Point F

Not applicable

Flash Point C

Not applicable

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