SCP0010

Sigma-Aldrich

Adrenomedullin 11-50 rat

Empirical Formula (Hill Notation):
C194H304N58O59S4
Peso molecular:
4521.10
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

Application

Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Susan D Brain et al.
Physiological reviews, 84(3), 903-934 (2004-07-23)
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves, whilst AM is produced by stimulated vascular cells, and amylin...
B Lin et al.
European journal of pharmacology, 260(1), 1-4 (1994-07-21)
The present study was undertaken to investigate the effects of human adrenomedullin, a newly discovered peptide present in normal human plasma, as well as a fragment of adrenomedullin, on systemic hemodynamics in the anesthetized rat. Intravenous (i.v.) bolus injections of...
A M Elhawary et al.
British journal of pharmacology, 115(7), 1133-1140 (1995-08-01)
1. Adrenomedullin is a novel vasoactive peptide which is produced in the lungs, ventricle, kidneys, heart and adrenal medulla. Adrenomedullin shows homology to calcitonin gene-related peptide (CGRP) and has similar pharmacological actions to CGRP. 2. This study examined the dose-response...
N Berthiaume et al.
Canadian journal of physiology and pharmacology, 73(7), 1080-1083 (1995-07-01)
The present work was undertaken to study the effect of rat adrenomedullin (rADM (1-50) and its C-terminal fragment (11-50)) in the endothelium-intact arterial and venous vasculatures of the rat perfused mesenteric bed. rADM (1-50) and the fragment rADM (11-50)(1-1000 pmol)...
J Cornish et al.
Current pharmaceutical design, 8(23), 2009-2021 (2002-08-13)
Bone growth is regulated by circulating hormones and locally generated factors. Understanding their mechanisms of action enables us to obtain a better appreciation of the cellular and molecular basis of bone remodelling, and could therefore be valuable in approaches to...

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