SCP0060

Sigma-Aldrich

CGRP II 8-37 human / β CGRP 8-37 human

Empirical Formula (Hill Notation):
C138H229N43O38S1
Peso molecular:
3130.63
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

Application

β-Calcitonin gene related peptide (β-CGRP) regulates cardiovascular homeostasis and nociception via G-coupled protein receptor (GCPR) calcitonin receptor-like receptor (CALCRL).
CGRP II 8-37 is used as a CGRP receptor antagonist.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Joseph J Lynch et al.
European journal of pharmacology, 623(1-3), 96-102 (2009-09-22)
The triptans, serotonin 5-HT(1B/1D) receptor agonists exemplified by sumatriptan, are a mainstay migraine therapy but have class labeling contraindicating their use in patients with coronary artery disease. Triptans constrict human coronary artery in vitro, and there are case reports of...
Toomas Talme et al.
Journal of neuroimmunology, 196(1-2), 60-66 (2008-04-22)
CGRP significantly stimulated migration of non-activated and anti-CD3 activated T lymphocytes into a collagen matrix when present inside the collagen, whereas somatostatin-14, NPY, substance P, VIP, beta-endorphin and metenkephalin had no or little effect. The CGRP antagonist CGRP 8-37 abrogated...
Vince T Nguyen et al.
Peptides, 33(1), 77-82 (2011-11-24)
Cardiac epinephrine and calcitonin gene-related peptide (CGRP) are produced by intrinsic cardiac adrenergic cells (ICA cells) residing in human and animal hearts. ICA cells are neuroparicine cells expressing δ-opioid receptors (DOR). We hypothesized that δ-opioid stimulation of ICA cells enhances...
I-Ching Hou et al.
Peptides, 30(12), 2228-2232 (2009-09-02)
We found that beta-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine beta-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.) or intraperitoneal administration at a dose of 40 nmol/mouse or 100mg/kg, respectively, in fasted...

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