Merck
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SCP0170

Sigma-Aldrich

Granulocyte Elastase Substrate human

Empirical Formula (Hill Notation):
C21H27N5O6
Molecular Weight:
445.47
NACRES:
NA.32

ensayo

≥95% (HPLC)

formulario

lyophilized

composición

Peptide Content, ≥85%

condiciones de almacenamiento

protect from light

temp. de almacenamiento

−20°C

Amino Acid Sequence

Glp-Pro-Val-pNA

Descripción general

Elastase, a glycoprotein, is a member of the serine proteases family. It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas. Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders.

Acciones bioquímicas o fisiológicas

Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin. Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.
Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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