Rong Geng et al.
Chinese journal of cancer, 36(1), 63-63 (2017-08-02)
The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes...
Xue-Cen Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(14), 4567-4579 (2019-04-14)
Neoadjuvant chemoradiotherapy (neoCRT) is a standard treatment for locally advanced rectal cancer (LARC); however, resistance to chemoradiotherapy is one of the main obstacles to improving treatment outcomes. The goal of this study was to identify factors involved in the radioresistance...
Davide Zecchin et al.
EMBO molecular medicine, 12(8), e11987-e11987 (2020-07-17)
Triple-negative breast cancer (TNBC) has poorer prognosis compared to other types of breast cancers due to the lack of effective therapies and markers for patient stratification. Loss of PTEN tumor suppressor gene expression is a frequent event in TNBC, resulting...
Ziyang Wang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(17), 2000593-2000593 (2020-10-01)
Colorectal cancer (CRC) has become a predominant cancer worldwide. To understand the process of carcinogenesis, a short hairpin RNA library screening is employed to search for candidate genes that promote proliferation in the CRC cell line HT29. The candidate genes...
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK.
Lin, Yu-yi, et al.