SMB00119

Sigma-Aldrich

Arjunolic acid

≥95% (LC/MS-ELSD)

Sinónimos:
2,3,23-Trihydroxyolean-12-en-28-oic acid
Empirical Formula (Hill Notation):
C30H48O5
Número de CAS:
Peso molecular:
488.70
MDL number:
PubChem Substance ID:
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥95% (LC/MS-ELSD)

form

solid

storage temp.

−20°C

SMILES string

CC1(C)CCC@@2(CCC@3(C)C(=CCC@@H4C@@5(C)CC@@H(O)C@H(O)C@@(C)(CO)C@@H5CCC@@34C)C@@H2C1)C(O)=O

InChI

1S/C30H48O5/c1-25(2)11-13-30(24(34)35)14-12-28(5)18(19(30)15-25)7-8-22-26(3)16-20(32)23(33)27(4,17-31)21(26)9-10-29(22,28)6/h7,19-23,31-33H,8-17H2,1-6H3,(H,34,35)/t19-,20+,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1

InChI key

RWNHLTKFBKYDOJ-DDHMHSPCSA-N

Categorías relacionadas

General description

Natural product derived from plant source.

Biochem/physiol Actions

Arjunolic acid (AA) is a triterpenoid saponin that has known anti-oxidant activity. AA has also shown promise in against type 1 diabetes through its prevention of hyperglycemia induced activation of MAPKs, PKC, NF-kB signaling cascades. Arjunolic acid is beneficial in protecting again acetaminophen (APAP)-induced liver and hepatocyte injury.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Prasenjit Manna et al.
Free radical biology & medicine, 48(11), 1465-1484 (2010-03-02)
Diabetic mellitus, a chronic metabolic disorder, is one of the most important health problems in the world, especially in developing countries. Our earlier investigations reported the beneficial action of arjunolic acid (AA) against streptozotocin-mediated type 1 hyperglycemia. We have demonstrated...
Jyotirmoy Ghosh et al.
Toxicology, 268(1-2), 8-18 (2009-11-20)
Acetaminophen (APAP) causes acute and chronic renal failure. The mechanisms leading to hepatic injury have been extensively studied, but the molecular mechanisms regarding APAP-induced nephro-toxicity are poorly defined. In earlier studies, we have demonstrated that arjunolic acid (AA) possesses protective...
Prasenjit Manna et al.
Free radical research, 46(7), 815-830 (2012-04-11)
In this review article, we describe the most recent development of the beneficial effect of arjunolic acid (AA) in reducing type 1 diabetic pathophysiology. Diabetic mellitus is a serious and growing health problem worldwide. Increasing evidence suggest that oxidative stress...
Sankhadeep Pal et al.
Toxicology, 283(2-3), 129-139 (2011-03-23)
Cadmium (Cd) is one of the ubiquitous environmental pollutants and is responsible for various organ pathophysiology including hepatic disorders. It is extremely toxic even in low concentrations and bioaccumulate in organisms. The present study has been carried out to investigate...
Rudiyansyah et al.
Journal of natural products, 69(8), 1218-1221 (2006-08-29)
Phytochemical exploration of a wood bark extract from Durio zibethinus afforded two new triterpenoids, namely, methyl 27-O-trans-caffeoylcylicodiscate (1) and methyl 27-O-cis-caffeoylcylicodiscate (2), a new phenolic, 1,2-diarylpropane-3-ol (3), and seven known compounds, fraxidin, eucryphin, boehmenan, threo-carolignan E, (-)-(3R,4S)-4-hydroxymellein, methyl protocatechuate, and...

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