Merck
All Photos(1)

SML0031

Sigma-Aldrich

DBeQ

≥98% (HPLC)

Synonym(s):
JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine
Empirical Formula (Hill Notation):
C22H20N4
Molecular Weight:
340.42
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: ≥20 mg/mL

temp. de almacenamiento

room temp

SMILES string

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChI key

QAIMUUJJAJBPCL-UHFFFAOYSA-N

Aplicación

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.[1]

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

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