Merck
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SML0055

Sigma-Aldrich

Securinine

≥98% (HPLC)

Empirical Formula (Hill Notation):
C13H15NO2
CAS Number:
Molecular Weight:
217.26
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

actividad óptica

[α]/D -980 to -1015 (C=1, MeOH)

color

yellow

solubilidad

DMSO: ≥25 mg/mL

temp. de almacenamiento

2-8°C

SMILES string

O=C1O[C@@]23C[C@@H](C=CC2=C1)N4CCCC[C@H]34

InChI

1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1

InChI key

SWZMSZQQJRKFBP-WZRBSPASSA-N

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Aplicación

Securinine was used as a standard in the synthesis of the members of Securinega alkaloid family.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

Características y beneficios

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictogramas

Skull and crossbones

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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