SML0070

Sigma-Aldrich

Salsalate

≥98% (HPLC)

Sinónimos:
2-Hydroxybenzoic acid 2-carboxyphenyl ester, salicyloxysalicylic acid, disalicylic acid, 2-(2-Hydroxybenzoyl)oxybenzoic acid, salicylsalicylic acid
Empirical Formula (Hill Notation):
C14H10O5
Número de CAS:
Peso molecular:
258.23
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

room temp

SMILES string

OC(=O)c1ccccc1OC(=O)c2ccccc2O

InChI

1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)

InChI key

WVYADZUPLLSGPU-UHFFFAOYSA-N

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Application

Salsalate was used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.

Packaging

50, 250 mg in glass bottle

Biochem/physiol Actions

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Codes

Xn,N

Risk Statement

22-50

Safety Statement

61

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

R F Carvalhal et al.
Biosensors & bioelectronics, 25(10), 2200-2204 (2010-04-07)
The use of an amperometric biosensor for rapid salicylate determination in blood is described. Photolitography was used to make gold electrodes on a polyester film. The plastic microcell was characterized using cyclic voltammetry to demonstrate the electrochemical performance of the...
J Koska et al.
Diabetologia, 52(3), 385-393 (2008-12-24)
Low-grade inflammation may contribute to obesity-related insulin resistance and has been associated with increased risk of type 2 diabetes mellitus. The present study evaluated whether treatment with salsalate, a traditional anti-inflammatory medication, would improve insulin action in obese non-diabetic individuals....
Roberta Noberini et al.
Chemical biology & drug design, 78(4), 667-678 (2011-07-28)
Eph receptor tyrosine kinases and ephrin ligands control many physiological and pathological processes, and molecules interfering with their interaction are useful probes to elucidate their complex biological functions. Moreover, targeting Eph receptors might enable new strategies to inhibit cancer progression...
Tae Woo Jung et al.
PloS one, 8(6), e66529-e66529 (2013-07-05)
Selenoprotein P (SeP) was recently identified as a hepatokine that induces insulin resistance (IR) in rodents and humans. Recent clinical trials have shown that salsalate, a prodrug of salicylate, significantly lowers blood glucose levels and increases adiponectin concentrations. We examined...
Kristen L Jablonski et al.
Hypertension (Dallas, Tex. : 1979), 57(1), 63-69 (2010-12-01)
We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation. Brachial artery flow-mediated dilation, a measure...

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