SML0370

Sigma-Aldrich

Kartogenin

≥98% (HPLC)

Sinónimos:
KGN, 2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI)
Empirical Formula (Hill Notation):
C20H15NO3
Número de CAS:
Peso molecular:
317.34
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >15 mg/mL

storage temp.

room temp

SMILES string

OC(=O)c1ccccc1C(=O)Nc2ccc(cc2)-c3ccccc3

InChI

1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)

InChI key

SLUINPGXGFUMLL-UHFFFAOYSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

Certificado de Análisis

Certificado de origen

Alix Barbe et al.
International journal of molecular sciences, 20(17) (2019-08-31)
Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0.01, 0.1...
Yoshitaka Imamichi et al.
The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)
11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. The objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression...
Jianying Zhang et al.
Bone research, 2 (2014-11-25)
Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to...
Mei Zhang et al.
Cell death & disease, 8(10), e3088-e3088 (2017-10-06)
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here...
Kartogenin induces cartilage-like tissue formation in tendon-bone junction
Zhang J and Wang J H C
Bone research, 2(1), 1-10 (2014)

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