Merck
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SML0472

Sigma-Aldrich

4-IPP

≥97% (HPLC)

Synonym(s):
4-Iodo-6-phenylpyrimidine
Empirical Formula (Hill Notation):
C10H7IN2
CAS Number:
Molecular Weight:
282.08
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad

100

ensayo

≥97% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 10 mg/mL (clear solution, warmed)

temp. de almacenamiento

−20°C

SMILES string

Ic1cc(ncn1)-c2ccccc2

InChI

1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H

InChI key

ZTCJXHNJVLUUMR-UHFFFAOYSA-N

Aplicación

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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