SML0472

4-IPP

≥97% (HPLC)

• Synonym(s): 4-Iodo-6-phenylpyrimidine
• Empirical Formula (Hill Notation): C₁₀H₇IN₂
• CAS Number: 41270-96-6
• Molecular Weight: 282.08
• Número MDL: MFCD00234609
• ID de la sustancia en PubChem: 329825428

Properties

• Nivel de calidad: 100
• ensayo: ≥97% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL (clear solution, warmed)
• temp. de almacenamiento: −20°C
• SMILES string: Ic1cc(ncn1)-c2ccccc2
• InChI: 1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
• InChI key: ZTCJXHNJVLUUMR-UHFFFAOYSA-N

Description

Aplicación

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3