Tienilic Acid

≥98% (HPLC)

Ticrynafen, Tienylic acid, 2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy-acetic acid
Empirical Formula (Hill Notation):
Número de CAS:
Peso molecular:
EC Number:
MDL number:
PubChem Substance ID:
En este momento no podemos mostrarle ni los precios ni la disponibilidad


≥98% (HPLC)




white to beige


DMSO: 5 mg/mL (clear solution)

shipped in

wet ice

storage temp.


SMILES string




InChI key



5, 25 mg in glass bottle

Biochem/physiol Actions

Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.

Features and Benefits

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Hazard Codes


Risk Statement



NONH for all modes of transport

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

E Bonierbale et al.
Chemical research in toxicology, 12(3), 286-296 (1999-03-17)
Tienilic acid (TA) is responsible for an immune-mediated drug-induced hepatitis in humans, while its isomer (TAI) triggers a direct hepatitis in rats. In this study, we describe an immunological approach developed for studying the specificity of the covalent binding of...
Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation.
M Belghazi et al.
Advances in experimental medicine and biology, 500, 139-144 (2002-01-05)
Peter M Rademacher et al.
Chemical research in toxicology, 25(4), 895-903 (2012-02-15)
The uricosuric diuretic agent tienilic acid (TA) is a thiophene-containing compound that is metabolized by P450 2C9 to 5-OH-TA. A reactive metabolite of TA also forms a covalent adduct to P450 2C9 that inactivates the enzyme and initiates immune-mediated hepatic...
Daisuke Satoh et al.
PloS one, 12(10), e0187072-e0187072 (2017-10-25)
The utility of HepG2 cells to assess drug metabolism and toxicity induced by chemical compounds is hampered by their low cytochrome P450 (CYP) activities. To overcome this limitation, we established HepG2 cell lines expressing major CYP enzymes involved in drug...
S Poli-Scaife et al.
Biochemistry, 36(42), 12672-12682 (1997-10-23)
Purified recombinant human liver cytochrome P450 2C9 was produced, from expression of the corresponding cDNA in yeast, in quantities large enough for UV-visible and 1H NMR experiments. Its interaction with several substrates (tienilic acid and two derivatives, lauric acid and...

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