SML0528

BIM5078

≥98% (HPLC)

• Sinónimos: 1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole, 1-(2-Chloro-5-nitrophenyl)sulfonyl-2-methyl-1H-benzimidazole
• Empirical Formula (Hill Notation): C₁₄H₁₀ClN₃O₄S
• Número de CAS: 337506-43-1
• Peso molecular: 351.76
• MDL number: MFCD01173148
• PubChem Substance ID: 329825533
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CC1=NC2=CC=CC=C2N1S(C3=C(Cl)C=CC(N+(O-)=O)=C3)(=O)=O
• InChI: 1S/C14H10ClN3O4S/c1-9-16-12-4-2-3-5-13(12)17(9)23(21,22)14-8-10(18(19)20)6-7-11(14)15/h2-8H,1H3
• InChI key: DLUVMRPVZILBOE-UHFFFAOYSA-N

Descripción

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BIM5078 is a potent Hepatocyte nuclear factor 4a (HNF4a) antagonist that directly binds to ligand-binding pocket and modulates the expression of known HNF4a target genes. BIM5078 also inhibits insulin gene expression by disruption of E47 and PDX-1 binding to insulin promoter. BIM5078 is selectively cytotoxic to transformed cells.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Codes: T
• Risk Statement: 25
• Safety Statement: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: WGK 3