≥97% (HPLC)

ST-1435, 17-(Acetyloxy)-16-methylene-19-norpregn-4-ene-3,20-dione, Nestoron, Elcometrine, 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate, ST1435
Empirical Formula (Hill Notation):
Número de CAS:
Peso molecular:
MDL number:
PubChem Substance ID:
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Quality Level


≥97% (HPLC)




white to beige


DMSO: 5 mg/mL, clear

storage temp.


SMILES string




InChI key


Gene Information

human ... PGR(5241)


10, 50 mg in glass bottle

Biochem/physiol Actions

Nestorone is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. Nestorone has been used as a female contraceptive, and recent studies inidicate that it may be useful as a male contraceptive as well. It has also been shown to have neurogenic and neuroprotective activity.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


NONH for all modes of transport

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Shuhua Chen et al.
Menopause (New York, N.Y.), 25(10), 1138-1151 (2018-05-31)
Neurogenesis is the principal regenerative mechanism to sustain the plasticity potential in adult brains. Decreased neurogenesis parallels the cognition decline with aging, and has been suggested as a common hallmark in the progression of many neurodegeneration diseases. We previously reported...
Mandana Rad et al.
Steroids, 77(13), 1483-1486 (2012-09-18)
OBJECTIVE & STUDY DESIGN: In a parallel design, 23 and 22 healthy pre-menopausal women were randomly administered a contraceptive vaginal ring (CVR) delivering 150/15 μg Nestorone®/ethinyl estradiol (EE) daily or an oral contraceptive (OC) containing levonorgestrel and EE (150/30 μg)...
Mandana Rad et al.
Contraception, 86(3), 231-237 (2012-03-27)
Discriminant analysis (DA) was performed on data of two combined hormonal contraceptives (CHC) differing in estrogen ratio to explore whether a combination of variables rather than a single variable distinguishes CHCs better. Data were used of a parallel study in...
Horatio B Croxatto et al.
Contraception, 73(1), 46-52 (2005-12-24)
The Nestorone/ethinylestradiol (NES/EE) vaginal ring is being developed as a regular contraceptive method by the Population Council. This ring is designed to release NES 150 microg/day and EE 15 microg/day during 1 year. Here, we report a Phase I clinical...
Edith Weisberg et al.
Contraception, 72(1), 46-52 (2005-06-21)
We examined the clinical performance of contraceptive vaginal rings (rings) delivering Nestorone (NES) progestin and ethinyl estradiol (EE). Ring removal times were signaled by menstrual events. Bleeding patterns, adverse events, patterns of use and continuation rates were the principal parameters...
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