Merck
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SML0583

Sigma-Aldrich

Ferrostatin-1

≥95% (HPLC)

Synonym(s):
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
Empirical Formula (Hill Notation):
C15H22N2O2
CAS Number:
Molecular Weight:
262.35
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥95% (HPLC)

formulario

powder

color

, faint purple to brown

solubilidad

DMSO: 10 mg/mL, clear

temp. de almacenamiento

2-8°C

Aplicación

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.[1][2]

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy.[3] Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.[4]

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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