SML0586

Lomeguatrib

≥98% (HPLC)

• Synonym(s): O6-(4-bromothenyl)guanine, 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
• Empirical Formula (Hill Notation): C₁₀H₈BrN₅OS
• CAS Number: 192441-08-0
• Molecular Weight: 326.17
• Número MDL: MFCD23703756
• ID de la sustancia en PubChem: 329825566
• NACRES: NA.77

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: room temp
• SMILES string: Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
• InChI: 1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
• InChI key: JUJPKFNFCWJBCX-UHFFFAOYSA-N

Description

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Lomeguatrib is a highly potent inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein which can confer resistance to some cancer chemotherapeutics, in particular the DNA alkylating agents such as Temozolomide, DTIC, Carmustine, etc. Lomeguatrib is a highly potent inactivator of MGMT and can be used to further investigate mechanisms of resistance. It is a potent irreversible inactivator of all mammalian O6-alkylguanine-DNA-alkyltransferases, so far tested with nanomolar activity in vitro and in vivo.

Safety Information

• pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 13 - Non Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable