≥98% (HPLC)

(-)-Daurisoline, (R,R)-Daurisoline, (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol, O7-Demethyldauricine
Empirical Formula (Hill Notation):
Número de CAS:
Peso molecular:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level


≥98% (HPLC)




white to beige


DMSO: 15 mg/mL, clear

storage temp.




InChI key



5, 25 mg in glass bottle

Biochem/physiol Actions

Daurisoline is antiarrythmic, anti-inflammatory, neuron-protective; and blocks hERG channels.
Daurisoline alkaloid isolated from the rhizomes of Menispermum dauricum that exhibit varies pharmacological activities including antiplatelet aggregation, anti-inflammatory, neuron-protective properties, and antiarrhythmic effect. It appears that antiarrhythmic effect of daurisoline is maintained through blockade of hERG channels.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


NONH for all modes of transport

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Y M Lu et al.
British journal of pharmacology, 104(1), 222-226 (1991-09-01)
1. The extracellular glutamate content and Ca2+ level in vivo in rat hippocampus were measured by brain microdialysis following administration of two depolarizing agents (veratridine, KCl) and quinolinic acid (Quin). 2. The two depolarizing agents increased the extracellular glutamate level...
J Che et al.
Chinese medical journal, 108(4), 265-268 (1995-04-01)
Cytosolic free Ca2+ ([Ca2+]i) was measured in dissociated cerebral cells isolated from fetal rats with the fluorescent indicater fura-2. Increase in [Ca2+]i occurred rapidly following exposure of the cells to 50 mmol/L KCl, 10(-7) mol/L Bay K 8644 or 200...
S Chen et al.
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 20(1), 39-42 (2003-07-09)
To establish the determination method of dauricine (Dau) concentration in rats' blood and other biological samples, a reverse-phase HPLC method was adopted. Under the given condition, dauricine could be well separated. The retention time (tR) of Dau and its internal...
Y M Lu et al.
British journal of pharmacology, 101(1), 45-48 (1990-09-01)
1. The effects of (-)-daurisoline on 45Ca2+ uptake and [3H]-gamma-aminobutyric acid ([3H]-GABA) release from synaptosomes of rat cerebral cortex and on contractile activity of rat aorta were examined. 2. Application of (-)-daurisoline (1-100 microM) produced concentration-related inhibition of high K(+)-stimulated...
Xiang-Ying Kong et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 40(10), 916-919 (2006-01-18)
To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on thrombosis and platelet aggregation, and to explore its mechanism of action. Thrombosis was observed with arteriovenous shunt thrombus model in rat; platelet aggregation was determined by Born's method;...

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