Merck
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SML0683

Sigma-Aldrich

JNJ-40418677

≥98% (HPLC)

Synonym(s):
2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid
Empirical Formula (Hill Notation):
C26H22F6O2
CAS Number:
Molecular Weight:
480.44
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 15 mg/mL, clear

emisor

Johnson & Johnson

enfermedades relevantes

Alzheimer′s disease

temp. de almacenamiento

2-8°C

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.

pictogramas

Skull and crossbones

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 2 Oral - Aquatic Chronic 4

Código de clase de almacenamiento

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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