SML0720

Sigma-Aldrich

Methazolamide

≥98% (HPLC)

Sinónimos:
5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide, N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide, L 584601, N-(4-Methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene) acetamide
Empirical Formula (Hill Notation):
C5H8N4O3S2
Número de CAS:
Peso molecular:
236.27
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

mp

208 °C (dec.) (lit.)

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O

InChI

1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+

InChI key

FLOSMHQXBMRNHR-QPJJXVBHSA-N

Gene Information

human ... CA1(759), CA2(760), CA4(762), CA7(766)

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Packaging

50 mg in glass bottle

Biochem/physiol Actions

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Light sensitive

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

pictograms

Exclamation markHealth hazard

signalword

Warning

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

The pharmacology of methazolamide in relation to the treatment of glaucoma.
Maren TH, et al.
Investigative Ophthalmology & Visual Science, 16(8), 730-742 (1977)
Ming-Tao Yang et al.
Psychopharmacology, 232(20), 3763-3772 (2015-08-01)
Dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (ADHD). Carbonic anhydrase (CA) has been reported to affect monoamine transmission in the central nervous system. The aim of this study is to investigate...

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