SML0762

Enzastaurin

≥98% (HPLC)

• Synonym(s): 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione, D04014, LY-317615, LY317615
• Empirical Formula (Hill Notation): C₃₂H₂₉N₅O₂
• CAS Number: 170364-57-5
• Molecular Weight: 515.60
• NACRES: NA.77

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• condiciones de almacenamiento: desiccated
• color: , light orange to dark orange-red
• solubilidad: DMSO: 10 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• InChI: 1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
• InChI key: AXRCEOKUDYDWLF-UHFFFAOYSA-N

Description

Aplicación

Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Enzastaurin is a potent and PKCβ preferring inhibitor. Also, Enzastaurin inhibits AKT and GSK3β. Enzastaurin acts as anti-angiogenic and antineoplastic agent.

It is an orally administered drug. It can induce apoptosis, inhibit angiogenesis and proliferation of cells. Enzastaurin can be used for the treatment of haematological cancers.

Características y beneficios

This compound is featured on the GSK-3, PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302 - H413
• Consejos de prudencia: P273 - P301 + P312 + P330
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Chronic 4
• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable