Merck
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SML0781

Sigma-Aldrich

NSC109555

≥98% (HPLC)

Synonym(s):
2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
Empirical Formula (Hill Notation):
C19H24N10O · 2CH3SO3H
CAS Number:
Molecular Weight:
600.67
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

H2O: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

InChI

1S/C19H24N10O.2CH4O3S/c1-11(26-28-17(20)21)13-3-7-15(8-4-13)24-19(30)25-16-9-5-14(6-10-16)12(2)27-29-18(22)23;2*1-5(2,3)4/h3-10H,1-2H3,(H4,20,21,28)(H4,22,23,29)(H2,24,25,30);2*1H3,(H,2,3,4)/b26-11+,27-12+;;

InChI key

HXDBGZUARNKHBV-XMDRLFCYSA-N

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.

Características y beneficios

This compound is featured on the Csk page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Certificate of Analysis

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Certificate of Origin

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Articles

c-Src kinase (Csk)

The C-terminal c-Src kinase (Csk) is a 50-kDa cytosolic tyrosine kinase expressed in all examined cell types

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