Merck
All Photos(2)

SML0788

Sigma-Aldrich

A 83-01

≥98% (HPLC)

Synonym(s):
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide, A-83-01, A83-01
Empirical Formula (Hill Notation):
C25H19N5S
CAS Number:
Molecular Weight:
421.52
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

−20°C

Aplicación

A 83-01 has been used as an inhibitor of transforming growth factor β kinase type 1 receptor.[1][2]

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

A 83-01 is a TGFβ kinase/activin receptor-like kinase (ALK 5) inhibitor (IC50=12 nM) that prevents phosphorylation of Smad2/3 and inhibits growth induced by TGFβ. A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Also, A 83-01 inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7. A-83-01 induces an expansion of neonatal Nkx2.5-eGFP (+) cells.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

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