Merck
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SML0798

Sigma-Aldrich

Osanetant

≥98% (HPLC)

Synonym(s):
SR-142801, SR142801, (R)-N-{{3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl}-4-phenylpiperidin-4-yl}-N-methylacetamine
Empirical Formula (Hill Notation):
C35H41Cl2N3O2
CAS Number:
Molecular Weight:
606.62

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

actividad óptica

[α]/D +17 to +24°, c = 1 in methanol

color

white to beige

solubilidad

DMSO: 15 mg/mL, clear

temp. de almacenamiento

−20°C

InChI

1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-20-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(42)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/s1

InChI key

DZOJBGLFWINFBF-UMSFTDKQSA-N

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Osanetant is a selective antagonist of neurokinin 3 receptor NK3. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Osanetant was in clinical trials for both irritable bowel syndrome and schizophrenia.

pictogramas

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Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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