Merck
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SML0883

Sigma-Aldrich

HIF-2 Antagonist 2

≥98% (HPLC)

Synonym(s):
N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine
Empirical Formula (Hill Notation):
C12H6ClFN4O3
CAS Number:
Molecular Weight:
308.65
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 15 mg/mL, clear

temp. de almacenamiento

room temp

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Hypoxia inducible transcription factors (HIF) control gene expression when oxygen availability is low and are associated with the onset and progression of a variety of cancers. They are heterodimers of an HIF-α (HIF-1α, HIF-2α also known as EPAS-1, or HIF-3α) and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β). N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine is a highly selective antagonist of HIF-2 heterodimerization, DNA-binding activity, and target gene transcription. It binds the HIF-2α PAS-B domain with a KD ~80 nM compared to a KD > 5000 nM for the HIF-1α PAS-B domain.

Características y beneficios

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Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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