Merck
All Photos(1)

SML0886

Sigma-Aldrich

Leukadherin-1

≥98% (HPLC)

Synonym(s):
4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid, Leukadherin 1, Leukadhedrin 1, LA1
Empirical Formula (Hill Notation):
C22H15NO4S2
CAS Number:
Molecular Weight:
421.49
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

, yellow to orange to brown

solubilidad

DMSO: 3 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.
Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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