Merck
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SML0919

Sigma-Aldrich

ML221

≥98% (HPLC)

Synonym(s):
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
Empirical Formula (Hill Notation):
C17H11N3O6S
CAS Number:
Molecular Weight:
385.35
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC50 of 1.75 μM.
ML221 is capable of suppressing the cultured-endothelial cell proliferation. In oxygen-induced retinopathy (OIR) mice model, ML221 can block the pathological angiogenesis and increase the recovery of normal vessels into the ischemic regions in the retina. It can also inhibit the formation of neovascular tufts.[1]

Características y beneficios

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Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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