SML0986

Sigma-Aldrich

Divin

≥98% (HPLC)

Sinónimos:
N′-[(E)-(2-Hydroxynaphthalen-1-yl)methylidene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide), 2-[(2-Hydroxy-1-naphthalenyl)methylene]hydrazide-2-methyl-1H-Benzimidazole-1-propanoic acid
Empirical Formula (Hill Notation):
C22H20N4O2
Número de CAS:
Peso molecular:
372.42
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

General description

Divin is formed by minicell locus C (minC) and minD gene products. Divin is a nonspecific inhibitor of septation. It has an ability to inhibit cell division at all potential division sites.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Divin (DIVision Inhibitor) is an inhibitor of bacterial division with a novel mechanism of action. During bacterial division, more than a dozen different proteins assemble at the division site in a specific order to form a complex called the divisome, with the first protein, FtsZ , followed by ‘early′ or ‘late′ proteins based on their temporal localization. Divin blocks cell division by disrupting the spatial and temporal localization of the late division proteins, disrupting their assembly and preventing compartmentalization of the cytoplasm. Divin has been found to be a potent bacteriostatic agent against clinical pathogens with low toxicity against mammalian cells.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
A Division Inhibitor and a Topological Specificity Factor Coded for by the Minicell Locus Determine Proper Placement of the Division Septum in E. coli.
de Boer P A, et al.
Cell, 56(4), 641-649 (1989)

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