Merck
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SML1021

Sigma-Aldrich

BC-1258

Synonym(s):
N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine
Empirical Formula (Hill Notation):
C22H22N4S2
CAS Number:
Molecular Weight:
406.57
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

ensayo

≥98% (HPLC)

Nivel de calidad

100

formulario

powder

color

white to beige

solubilidad

DMSO: 10 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

SMILES string

C1(C2=NC=CS2)=CC=C(CNCCNCC3=CC=C(C4=NC=CS4)C=C3)C=C1

InChI

1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2

InChI key

FRTSLZJCGAFSET-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

BC-1258 is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. BC-1258 induces mitotic arrest and apoptosis of tumorigenic cells. Also BC-1258 inhibits tumor formation in athymic nude mice.

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