SML1045

Thiazovivin

≥98% (HPLC)

• Synonym(s): N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
• Empirical Formula (Hill Notation): C₁₅H₁₃N₅OS
• CAS Number: 1226056-71-8
• Molecular Weight: 311.36
• NACRES: NA.77

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• color: , white to beige to brown
• solubilidad: DMSO: 20 mg/mL, clear
• temp. de almacenamiento: −20°C

Description

Aplicación

Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Thiazovivin is a Rho Kinase (ROCK) inhibitor that promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method when used in combination with ALK5 inhibitor SB-431542 (S4317) and MEK inhibitor PD-0325901 (PZ0162). Thiazovivin stabilizes E-cadherin on the cell surface, necessary for human embryonic stem cell survival in culture. When human embryonic stem cells are cut out from the colony, this key protein is disrupted and then internalized within the cell. Without e-cadherin on the cell surface, cell signaling between the cells and their environment is disrupted and the cells quickly die.

Thiazovivin is an inhibitor of Rho associated coiled-coil containing protein kinase (ROCK). In vitro studies prove that thiazovivin is efficient in stimulating better morphology, expression of ionic transporter and protein involved in cell adhesion.

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable