Merck
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SML1064

Sigma-Aldrich

IMM-01

≥98% (HPLC)

Synonym(s):
2-[(2,4-Dihydroxyphenyl)methylene]-N-(1,1-dimethylethyl)-hydrazinecarbothioamide, Intramimic-01, N1-(tert-Butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide
Empirical Formula (Hill Notation):
C12H17N3O2S
CAS Number:
Molecular Weight:
267.35
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to light brown

solubilidad

DMSO: 10 mg/mL, clear

temp. de almacenamiento

2-8°C

Aplicación

IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs).

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

IMM-01 binds and activates formin thereby leading to autoinhinition.
IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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