SML1080

Sigma-Aldrich

BRD7116

≥98% (HPLC)

Sinónimos:
N,N′-(Sulfonyldi-4,1-phenylene)bis2,2,3,3-tetramethyl-cyclopropanecarboxamide, 2,2,3,3-Tetramethyl-N-4-4-(2,2,3,3-tetramethylcyclopropanecarbonyl)aminophenylsulfonylphenylcyclopropane-1-carboxamide
Empirical Formula (Hill Notation):
C28H36N2O4S
Número de CAS:
Peso molecular:
496.66
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C1C(NC(C=C2)=CC=C2S(C3=CC=C(NC(C4C(C)(C(C)4C)C)=O)C=C3)(=O)=O)=O)(C(C)1C)C

InChI

1S/C28H36N2O4S/c1-25(2)21(26(25,3)4)23(31)29-17-9-13-19(14-10-17)35(33,34)20-15-11-18(12-16-20)30-24(32)22-27(5,6)28(22,7)8/h9-16,21-22H,1-8H3,(H,29,31)(H,30,32)

InChI key

UHXFWAHRAMUDLJ-UHFFFAOYSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BRD7116 is a selective inhibitor of leukemia stem cells. BRD7116 had an EC50 of 200 nM for the leukemia stem cell (LSC)-enriched fraction of cells isolated from the bone marrow of leukemic animals in co-culture compared to ~50% inhibition at 20 μM against normal hematopoietic stem and progenitor cells (HSPCs) and AML cell lines. BRD7116 selectively targeted LSCe cells by cell-autonomous and cell-non-autonomous mechanisms. The exact mechanism is not known, but involved in impairing of the stroma′s ability to support leukemia cells, and inducing transcriptional changes consistent with myeloid differentiation.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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