SML1116

Sigma-Aldrich

PQ-10

≥98% (HPLC)

Sinónimos:
PQ 10, 6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-quinazoline
Empirical Formula (Hill Notation):
C22H21N5O3
Número de CAS:
Peso molecular:
403.43
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

COC1=CC2=C(N3C[C@H](OC4=CN=C(C=CC=C5)C5=N4)CC3)N=CN=C2C=C1OC

InChI

1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1

InChI key

UBIIFKJMNRPNMT-CQSZACIVSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.
PQ-10 (6,7-dimethoxy-4-[3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline), is capable of suppressing tumor cell growth. It can also reverse the RO-4-1284-induced sedation and catalepsy.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and beta-catenin-dependent TCF transcriptional activity
Li N, et al.
Oncogene, 34(12), 1499-1499 (2015)
Quality of life and non-motor symptoms in Parkinson's disease patients with subthreshold depression.
Santos-Garcia, et al.
Journal of the Neurological Sciences, 418, 117109-117109 (2020)
PDE 10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways
Megens AAHP, et al.
Pharmacology Research & Perspectives, 2(4), e00057-e00057 (2014)
Contenido relacionado
Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.
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