Merck
All Photos(1)

SML1135

Sigma-Aldrich

MG-132(R)

≥95% (HPLC)

Synonym(s):
Z-L-Leu-D-Leu-L-Leu-al
Empirical Formula (Hill Notation):
C26H41N3O5
CAS Number:
Molecular Weight:
475.62
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.32

Línea del producto

SAFC Hitech®

Nivel de calidad

200

ensayo

≥95% (HPLC)

formulario

powder

solubilidad

DMSO: soluble

temp. de almacenamiento

−20°C

SMILES string

O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-ZRBLBEILSA-N

Gene Information

Acciones bioquímicas o fisiológicas

MG-132(R) is a potent, membrane-permeable proteasome inhibitor.[1] It induces neurite outgrowth in PC12 cells at 10 M. MG-132(R) blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. However, MG-132(R) also activates c-Jun N-terminal protein kinase (JNK-1), which initiates apoptosis in response to cell stress. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types.

Información legal

SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service