Merck
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SML1270

Sigma-Aldrich

YZ9

≥98% (HPLC)

Synonym(s):
7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester, 3-Carbethoxy-7-hydroxycoumarin
Empirical Formula (Hill Notation):
C12H10O5
CAS Number:
Molecular Weight:
234.20
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

−20°C

InChI

1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3

InChI key

IETDBZQIWIJQJG-UHFFFAOYSA-N

Envase

10, 50 mg in glass bottle

Acciones bioquímicas o fisiológicas

YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC50 = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.
YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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