Merck
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SML1466

Sigma-Aldrich

ABH hydrochloride

≥98% (HPLC)

Synonym(s):
6-Borono-L-norleucine hydrochloride, 2(S)-Amino-6-boronohexanoic acid hydrochloride
Empirical Formula (Hill Notation):
C6H14BNO4 · HCl
CAS Number:
Molecular Weight:
211.45
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

actividad óptica

[α]/D +8 to +13°, c = 0.7 in H2O

color

white to beige

solubilidad

H2O: 20 mg/mL, clear

temp. de almacenamiento

2-8°C

SMILES string

OB(O)CCCC[C@H](N)C(O)=O.[H]Cl

InChI

1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1

InChI key

XCUVEZUCSHVMRK-JEDNCBNOSA-N

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.
ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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