Merck
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SML1477

Sigma-Aldrich

MPI-0479605 hydrochloride

≥98% (HPLC)

Synonym(s):
N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine hydrochloride
Empirical Formula (Hill Notation):
C22H29N7O · HCl
CAS Number:
Molecular Weight:
443.97
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

−20°C

SMILES string

CC(C=C(N1CCOCC1)C=C2)=C2NC3=NC4=C(N=CN4)C(NC5CCCCC5)=N3.[H]Cl

InChI

1S/C22H29N7O.ClH/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16;/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,25,26,27,28);1H

InChI key

BYBIFMLUJUNGNX-UHFFFAOYSA-N

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

MPI-0479605 is a potent ATP-competitive inhibitor of the dual-specificity kinase Mps-1, which is essential for maintainence of spindle assembly checkpoint and chromalomal spindle attachment. Treatment of cells with MPI-0479605 causes aberrant mitosis and aneuploidy and inhibits growth of tumor xenografts in vivo. MPI-0479605 has an IC50 value of 1.8 nM.

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