Merck
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SML1509

Sigma-Aldrich

MK6-83

≥98% (HPLC)

Synonym(s):
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Empirical Formula (Hill Notation):
C16H20N2O2S2
CAS Number:
Molecular Weight:
336.47
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to brown

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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