SML1635

Sigma-Aldrich

Brassinin

≥98% (HPLC)

Sinónimos:
Methyl N-(1H-indol-3-ylmethyl)-carbamodithioate, Brassinine, N-(1H-indol-3-ylmethyl)-carbamodithioic acid methyl ester
Empirical Formula (Hill Notation):
C11H12N2S2
Número de CAS:
Peso molecular:
236.36
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

S=C(SC)NCC1=CNC2=C1C=CC=C2

InChI

1S/C11H12N2S2/c1-15-11(14)13-7-8-6-12-10-5-3-2-4-9(8)10/h2-6,12H,7H2,1H3,(H,13,14)

InChI key

QYKQWFZDEDFELK-UHFFFAOYSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Brassinin is a phytoalexin isolated from cruciferous vegetables that exhibits anticancer, chemopreventive, antiproliferative and antifungal activities. In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3. It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling.

Other Notes

air sensitive

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Bobin Kang et al.
The Journal of pharmacy and pharmacology, 72(9), 1245-1255 (2020-05-23)
The effects and molecular mechanisms of brassinin (BR), an indole phytoalexin from cruciferous vegetables, on monocyte-to-macrophage differentiation and inflammatory responses were investigated in this study. Inflammatory responses from RAW264.7 cells and THP-1 were stimulated by lipopolysaccharide (1 µg/ml), and monocyte-to-macrophage differentiation...
Andrea Angarita-Rodríguez et al.
Molecules (Basel, Switzerland), 25(1) (2019-12-28)
There is a continuous search for more reliable and effective alternatives to control phytopathogens through different strategies. In this context, indole-containing phytoalexins are stimuli-induced compounds implicated in plant defense against plant pathogens. However, phytoalexins' efficacy have been limited by fungal...

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