Merck
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SML1831

Sigma-Aldrich

KYA1797K potassium salt

≥98% (HPLC)

Synonym(s):
(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt, (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid potassium salt, KYA1797 potassium salt
Empirical Formula (Hill Notation):
C17H11KN2O6S2
CAS Number:
Molecular Weight:
442.51

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

orange to dark red

solubilidad

DMSO: 2 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

SMILES string

[O-]C(CCN1C(/C(SC1=S)=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O)=O.[K+]

Envase

5, 25 mg in glass bottle

Acciones bioquímicas o fisiológicas

KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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