Merck
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SML1839

Sigma-Aldrich

PFM39

≥98% (HPLC)

Synonym(s):
(5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone, 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one
Empirical Formula (Hill Notation):
C10H9N3OS
CAS Number:
Molecular Weight:
219.26

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

yellow to orange

solubilidad

DMSO: 15 mg/mL, clear

temp. de almacenamiento

2-8°C

SMILES string

NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1

Acciones bioquímicas o fisiológicas

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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