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SML1930

Sigma-Aldrich

CORM-401

Synonym(s):
Mn(CO)4{S2CNMe(CH2CO2H)}, Tetracarbonyl[N-(dithiocarboxy-?S,?S′)-N-methylglycine]manganate
Empirical Formula (Hill Notation):
C8H6MnNO6S2
CAS Number:
Molecular Weight:
331.20
NACRES:
NA.77

formulario

powder

Nivel de calidad

100

condiciones de almacenamiento

protect from light

color

light yellow to dark yellow

solubilidad

DMSO: 10 mg/mL, clear

temp. de almacenamiento

−20°C

SMILES string

CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1

Acciones bioquímicas o fisiológicas

CORM-401 (Mn(CO)4(S2CNMe(CH2CO2H))) is a manganese-containing carbon monoxide-releasing molecule (CORM) that generates at least three molar equivalents of CO. Due to reversible binding of CO, CORM-401 is relatively stable in solution (0.33 mol eq of CO loss after 4 h in PBS; [CORM-401] = 1 mM at time zero), while increased CO release occurs in the presence of a CO receptor or a ligand to prevent the rebinding of CO (3.2 mol eq of CO transferred to iron with a t1/2 of 0.8 min in the presence of 44 μM myoglobin; [CORM-401] = 10 μM at time zero). CO administration by CORM-401 is reported to uncouple mitochondrial respiration and inhibit glycolysis in human endothelial cells (10-100 μM), and relax isolated rat aortic rings (25 μM) pre-contracted with phenylephrine.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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