SML1942

Sigma-Aldrich

Drotaverine hydrochloride

≥95% (HPLC)

Sinónimos:
1-(3,4-Diethoxyphenyl)methylene-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, Drotaverin hydrochloride, Tetraspasmin-Lefa, 3′,4′,6,7-Tetraethoxy-1-benzylidene-1,2,3,4-tetrahydroisoquinoline hydrochloride
Empirical Formula (Hill Notation):
C24H31NO4 · HCl
Número de CAS:
Peso molecular:
433.97
MDL number:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CCOC1=CC=C(/C=C2C3=C(CCN/2)C=C(OCC)C(OCC)=C3)C=C1OCC.HCl

InChI

1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;

InChI key

JBFLYOLJRKJYNV-MASIZSFYSA-N

Biochem/physiol Actions

Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker that exhibits in vivo antispasmodic efficacy without anticholinergic effects.
It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.

pictograms

Exclamation mark

signalword

Warning

hcodes

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Zoltán Patai et al.
The Journal of pharmacology and experimental therapeutics, 359(3), 442-451 (2016-10-16)
Drotaverine is considered an inhibitor of cyclic-3',5'-nucleotide-phophodiesterase (PDE) enzymes; however, published receptor binding data also support the potential L-type voltage- operated calcium channel (L-VOCC) blocking effect of drotaverine. Hence, in this work, we focus on the potential L-VOCC blocking effect...
A G Stepaniuk et al.
Eksperimental'naia i klinicheskaia farmakologiia, 61(4), 17-19 (1998-10-23)
The study was conducted on experimental models of pain sense induced in mice by exposure to thermic or chemical factors and in rats by exposure to electric factors. Nitrosorbide and no-spa possess a dose-dependent analgesic effect. Both drugs excelled analgin...
Zsuzsanna Tömösközi et al.
European journal of pharmacology, 449(1-2), 55-60 (2002-08-07)
The effect of the isoquinoline derivative, drotaverine on the specific binding of [(3)H]nitrendipine and [(3)H]diltiazem to pregnant rat uterine membranes was examined. Drotaverine inhibited the specific [(3)H]nitrendipine and [(3)H]diltiazem bindings with IC(50) values of 5.6 and 2.6 microM, respectively. Saturation...
Corradini D, et al.
Handbook of HPLC (2011)

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