Merck
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SML1961

Sigma-Aldrich

EF5

≥98% (HPLC)

Synonym(s):
EF-5, NSC 684681, 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
Empirical Formula (Hill Notation):
C8H7F5N4O3
CAS Number:
Molecular Weight:
302.16
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 10 mg/mL, clear

temp. de almacenamiento

2-8°C

SMILES string

O=C(NCC(F)(F)C(F)(F)F)CN1C=CN=C1[N+]([O-])=O

Acciones bioquímicas o fisiológicas

EF5 is a 2-nitroimidazole-based hypoxia marker corresponding to a pentafluorinated derivative of the hypoxic cell-radiation sensitizer etanidazole. Under low oxygen (hypoxic) condition, reductive activation of its 2-nitroimidazole moiety leads to enhanced EF5 adduct formation with protein thiols and reduced glutathione. The pentafluorination derivatization substantially decreases the proportion of low molecular weight hydrolytic fragmentation of the adducts, making EF5 superior to etanidazole when utilized as a hypoxia marker by immunohistological staining.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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